Phage Display

Phage display is a selection technique used in biopharmaceutical manufacturing to isolate proteins with desired properties (e.g. specificity, affinity, stability) for a given effect. The advantage of this technique is that it enables a direct link between an expressed protein and its genetic sequence (genotype-phenotype linkage), as a protein’s genetic sequence can directly be extracted from an isolated phage. The process of phage display is shown below.

 

phage displayCreated with  Biorender.com.