lino Biotech

Discover Molecular Interactions

Company Profile

lino Biotech is the world´s only provider of Focal Molography – an entirely new method for measuring molecular interactions in living cells or crude biological samples. The broadly patented technology offers label-free detection assays while eliminating signal disturbances due to temperature changes or non-specific binding. lino Biotech was incorporated in Zürich, Switzerland, in March 2020 with the aim to make cell therapies more cost effective and accessible for a broader patient population by offering new quality control method that every cell therapy manufacturer can use to improve their production and development process.

label-free

Label-free

Focal Molography is a label-free interaction technology able to characterize a plurality of important interactions.

Stable

Stable

Due to its nano-sized, self-referencing principle Focal Molography offers a unique signal stability regarding environmental influences.

real-time

Real-Time

Biological interactions are monitored in real-time to obtain more relevant data than with other technologies.

Multiplexed

Multiplexed

Due to its label-free nature, focal molography is well suited for multiplexed assays, minimizing cross-talk between reagents.

Fast

Fast

No pre-equilibration with buffer or temperature stabilizations of the sensor is required for the measurement. This allows for an immediate start of the measurement.

Complex samples

By its physical nature, focal molography is compatible with complex media and cell-based assays allowing a new data dimension for scientists.

Current approach:

Trying to tackle analytical challenges, device manufacturers have ramped up engineering and data processing efforts. For customers, these strategies result in unfavorable solutions:

  • Extensive sample preparation
  • Risk of artifacts due to sample group
  • Complex assay design
  • Expensive equipment and sensor

Our solution:

lino´s biosensors and readers enable much faster and more accurate characterization of cell therapy products while at the same time helping the manufactures to substantially reduce production cost. Speeding up product QC, lowering production cost and improving safety of cell and gene therapies.

  • No sample purification
  • Simple assay design
  • Faster results
  • Offering novel QC options

Focal Molography

In short, focal molography is a nanotechnology-based method that cleverly combines photolithography, molecular self-assembly and state-of-the-art optical technology. It is a truly interdisciplinary technology, inspired by physics, tailored for biology and implemented for biomolecular interaction analysis.

Central to the technology is a biological surface structure termed mologram, which is part of our patented sensor chip. Bound biomolecules on the mologram function as “detectives” that recognize the target analyte in the sample through molecular recognition and selective binding and thereby emit a light signal.

This signal indicates the exact measure of binding affinity between recognition site and analyte. This coherent signal is measured in the molographic focus by the instrument’s detector array. One diffraction-limited mologram spot, less than one micrometre in diameter, represents one binding signal. Multiple molograms can be assembled on a tiny chip, meaning that multiple parameters can be measured swiftly, with great selectivity and sensitivity.

Learn more

“The reliable detection of molecular interactions in the life sciences might take an unexpected high-tech turn: Lithography on a nanometre scale makes it possible to distinguish between specific and non-specific binding on the surface of a chip.”
Dr. Christof Fattinger; 2016

This “high-tech turn” was achieved in 2019 and lino Biotech was founded to unleash the potential of diffractometric biosensors for sensitive and robust diffractometric biomolecular interaction analysis.

Stay tuned for more information

Founder Team

Dr. Mirko Stange

Dr. Volker Gatterdam

Dr. Andreas Frutiger

Dr. Tilman Hoss

Get to know us.