lino Biotech | Complex-Matrix Kinetics

The MACS^® Matchmaker powers every application above. It delivers kinetics in the matrix that matters.

Focal molography measures coherent mass density. Specifically bound analyte counts toward signal. Everything else, drift, non-specific binding, sample matrix noise, stays invisible. That is why kinetics in serum, lysate, or crude supernatant come out as clean as in buffer.

Run up to 64 interactions in parallel on a single chip. Cross-species half-life predictions in one experiment. Ternary complexes for PROTACs in lysate. Biosimilar comparability below the SPR noise floor. In hours, not weeks.

The same chip from discovery to lot release. Candidate ranking in early development and biosimilar comparability later run on the same 8-plex format and the same workflow, with no method redevelopment in between. Each ligand sits on eight replicate molograms, returning mean and confidence interval from a single experiment.

Crude samples

Pre-purification eats weeks. Your binder fails when the matrix changes from buffer to lysate or serum.

Measure directly in serum, lysate, or cell supernatant. No purification, no method redevelopment.

Background masks signal

Labels and NSB hide the real binding event. Real hits slip through as false negatives.

Focal molography reads coherent mass density. Non-specific binding and matrix noise stay structurally invisible.

Multi-week panels

Sequential SPR sweeps stall every decision. Cross-species FcRn, biosimilar comparability, off-rate ranking all wait in line.

Eight pre-conjugated ligands on one chip. The full cross-species panel runs in approximately one hour.

Sub-twofold gaps

Critical 1.5× differences disappear. Below the NSB floor, the data you need to rank candidates is invisible.

Eight within-chip replicates per ligand. Confidence intervals from a single run resolve sub-twofold differences.

One pair at a time

Conventional kinetics runs sample-by-sample. 64 simultaneous interactions stay on the to-do list.

Up to 64 simultaneous interactions on a single chip. One injection series delivers the full panel.

Drift-limited weak binders

Slow off-rates wash away in baseline drift before a clean curve can be fit.

Drift below 0.05 pg/mm²/min. Long association phases stay rock-stable, even at low-µM K_D.