Company Profile
lino Biotech is the world´s only provider of Focal Molography – an entirely new method for measuring molecular interactions in living cells or crude biological samples. The broadly patented technology offers label-free detection assays while eliminating signal disturbances due to temperature changes or non-specific binding. lino Biotech was incorporated in Zürich, Switzerland, in March 2020 with the aim to make cell therapies more cost effective and accessible for a broader patient population by offering new quality control method that every cell therapy manufacturer can use to improve their production and development process.
Label-free
Focal Molography is a label-free interaction technology able to characterize a plurality of important interactions.
Stable
Due to its nano-sized, self-referencing principle Focal Molography offers a unique signal stability regarding environmental influences.
Real-Time
Biological interactions are monitored in real-time to obtain more relevant data than with other technologies.
Multiplexed
Due to its label-free nature, focal molography is well suited for multiplexed assays, minimizing cross-talk between reagents.
Fast
No pre-equilibration with buffer or temperature stabilizations of the sensor is required for the measurement. This allows for an immediate start of the measurement.
Complex samples
By its physical nature, focal molography is compatible with complex media and cell-based assays allowing a new data dimension for scientists.
Our biosensors and readers enable much faster and more accurate characterization of cell therapy products while at the same time helping the manufactures to substantially reduce production cost. Speeding up product QC, lowering production cost and improving safety of cell and gene therapies.
no sample purification
simple assay design
faster results
offering novel QC options
Focal Molography
In short, focal molography is a nanotechnology-based method that cleverly combines photolithography, molecular self-assembly and state-of-the-art optical technology. It is a truly interdisciplinary technology, inspired by physics, tailored for biology and implemented for biomolecular interaction analysis.
Central to the technology is a biological surface structure termed mologram, which is part of our patented sensor chip. Bound biomolecules on the mologram function as “detectives” that recognize the target analyte in the sample through molecular recognition and selective binding and thereby emit a light signal.
This signal indicates the exact measure of binding affinity between recognition site and analyte. This coherent signal is measured in the molographic focus by the instrument’s detector array. One diffraction-limited mologram spot, less than one micrometre in diameter, represents one binding signal. Multiple molograms can be assembled on a tiny chip, meaning that multiple parameters can be measured swiftly, with great selectivity and sensitivity.
“The reliable detection of molecular interactions in the life sciences might take an unexpected high-tech turn: Lithography on a nanometre scale makes it possible to distinguish between specific and non-specific binding on the surface of a chip.”
Dr. Christof Fattinger; 2016This “high-tech turn” was achieved in 2019 and lino Biotech was founded to unleash the potential of diffractometric biosensors for sensitive and robust diffractometric biomolecular interaction analysis.
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Founder Team
Dr. Mirko Stange
Dr. Volker Gatterdam
Dr. Andreas Frutiger
