Company Profile

lino Biotech is the world´s only provider of Focal Molography – a novel label-free biosensor platform for direct imaging of biomolecular interactions in living cells. Molography enables our customers to measure molecular interactions in a more robust and more sensitive way while offering unique information for cell-based assays.



Focal Molography is a label-free interaction technology able to characterize a plurality of important interactions.



Due to its nano-sized, self-referencing principle Focal Molography offers a unique signal stability regarding environmental influences.



Biological interactions are monitored in real-time to obtain more relevant data than with other technologies.



Due to its label-free nature, focal molography is well suited for multiplexed assays, minimizing cross-talk between reagents.



No pre-equilibration with buffer or temperature stabilizations of the sensor is required for the measurement. This allows for an immediate start of the measurement.



By its physical nature, focal molography is compatible with complex media and cell-based assays allowing a new data dimension for scientists.

Focal Molography

In short, focal molography is a nanotechnology-based method that cleverly combines photolithography, molecular self-assembly and state-of-the-art optical technology. It is a truly interdisciplinary technology, inspired by physics, tailored for biology and implemented for biomolecular interaction analysis.

Central to the technology is a biological surface structure termed mologram, which is part of our patented sensor chip. Bound biomolecules on the mologram function as “detectives” that recognize the target analyte in the sample through molecular recognition and selective binding and thereby emit a light signal.

This signal indicates the exact measure of binding affinity between recognition site and analyte. This coherent signal is measured in the molographic focus by the instrument’s detector array. One diffraction-limited mologram spot, less than one micrometre in diameter, represents one binding signal. Multiple molograms can be assembled on a tiny chip, meaning that multiple parameters can be measured swiftly, with great selectivity and sensitivity.

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“The reliable detection of molecular interactions in the life sciences might take an unexpected high-tech turn: Lithography on a nanometre scale makes it possible to distinguish between specific and non-specific binding on the surface of a chip.”
Dr. Christof Fattinger; 2016

This “high-tech turn” was achieved in 2019 and lino Biotech was founded to unleash the potential of diffractometric biosensors for sensitive and robust diffractometric biomolecular interaction analysis.

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