Universal Chip Architecture
Sensor Chips
Our universal chip architecture can tackle various applications addressing major pain points in novel cell and gene therapy. Know-how of 10 years is embedded in chip coating & ability to structure active lines to serve as molecular lens on chip surface.
One Chip Design.
Endless Opportunities
Our universal chip architecture can tackle various applications addressing major pain points in novel cell and gene therapy. Biological functionalization of a MoloChip can be easily achieved by DNA-directed immobilization with a set of well characterized DNA sequences.
Orthogonal nature of the DNA directed immobilization in combination with the provided single – or six channel flow chambers allows for various subset combinations of lino´s MoloChips.
The sensor chip production is our core know-how. We successfully built on the established lithography-based single sensor fabrication process, two further suitable industrially accepted fabrication methods are currently under development. We have established a partner network to develop the four major components (the Optomechanic, the sensor chip, the liquid handling, the data evaluation software), while the operating software is being programmed inhouse by lino Biotech´s employees.
lino Biotech´s Sensor Chips
Our sensor chips are ready for you to be used or they can be functionalized according to our customers needs in a simple process using established conjugation techniques. Each sensor chip has 54 mologram structures which can be functionalized in various ways. Since every mologram has its own focal point, parallel label-free multiplexing can be achieved easily. In combination with a single or six-chanell fluidic chamber, different sensor chip formats can be implemented via simple combinatorics.
1x Molochip
1 capture single stranded DNA (ssDNA) sequence* fabricated by dip-coating or flow chamber modification.
Launch 2022
6x Molochip
6 orthogonal capture ssDNA sequences fabricated by flow chamber modification or micro spotting.
Launch 2023
54x Molochip
54 orthogonal capture ssDNA sequences fabricated by micro spotting.
Launch 2024
*colors represent different chemical functionalities
Protein A/G Sensor Chips
Improve your assay performance with our Protein A/G Sensor Chips. Our backfilled Chips allow you to measure directly in complex samples.
Streptavidin Sensor Chips
lino Biotech´s Streptavidin Sensor Chips are perfect for immobilizing biotinylated ligands (e.g. proteins, antibodies, and more).
Biological molecules, including proteins and nucleic acids, can be biotinylated using established protocols and immobilized onto the Streptavidin biosensor surface for custom assay development. There are many biotinylated biomolecules commercially available.
More about our sensor chips, e.g. a schematric illustration of the reactive immersion lithography (RIL), which allows the creation of the biomolecular recognition structure of the mologram on a light-sensitive non-fouling graft copolymer layer, can be found in our publication.
For more answered questions regarding our products, visit our FAQ.
We offer contract research. Interested for more?
Sensor Chips
– An Overview
In general, incorporating semiconductor circuit elements, used to convert changes to some physical parameter to an electrical signal are defined as sensor chips. The size and the format usually differs between manufacturers. They can be a solid state potentiometric, ampermetric and/or conductometric microsensor device or also an integrated group of such devices. The optical configuration and the fluidics are important, and can be seen as the heart of an biosensor. In our case, lino Biotech´s universal sensor chip architecture can tackle various applications, used to address major pain points in novel cell and gene therapy. Biological functionalization of a MoloChip can be easily achieved by DNA-directed immobilization with a set of well characterized DNA sequences. Orthogonal nature of the DNA directed immobilization in combination with the provided single – or six channel flow chambers allows for various subset combinations of lino´s MoloChips.
Lino Biotech´s
Sensor Chips
Lino Biotech developed those chips and that results in know-how of more then 10 years, embedded in chip coating and the ability to structure active lines to serve as molecular lens on the chips surface. The production it one of the core knowledges of lino Biotech. The synthesis of molograms on a planar optical waveguide on a chip succeeds with properly designed surface chemistry and reactive immersion lithography (RIL).
The RIL allows the creation of the biomolecular recognition structure of the mologram on a light-sensitive non-fouling graft copolymer layer. The synthesis of molograms avoids steric hindrance between the binding sites of the mologram that would occur from overcrowding of molecules in the coherent molographic assembly on the chip.
Different sensor chips
for different assays
We have different chips available for different applications. It is possible to improve your assay performance with our Protein A/G sensor chip, because they are backfilled, even measuring directly in complex samples is possible. The Streptavidin Chips are perfect for immobilizing biotinylated ligands (as proteins, antibodies and more), meaning biological molecules, including proteins and nucleic acids can be biotinylated using established protocols and immobilized onto the Streptavidin biosensor surface for custom assay development.
Usage of our sensor chips
Our sensor chips are ready for you to be used or they can be functionalized according to our customers needs in a simple process using established conjugation techniques. Each sensor chip has 54 mologram structures which can be functionalized in various ways. Since every mologram has its own focal point, parallel label-free multiplexing can be achieved easily. In combination with a single or six-chanel fluidic chamber, different sensor chip formats can be implemented via simple combinatorics. Possible applications of molography are vast. They range from the investigation of a specific biomolecular interaction in basic biological research to the diagnosis of a critical health condition in an emergency. To sum it up, in molography, biomolecules on a chip become apparent through diffraction, their coherent signal standing out from the speckle background generated by randomly arranged scatterns. The signal is hardly affected by changes due to temperature or buffer changes, or nonspecific bindings.
Frequently asked questions
A sensor is a device that produces an output signal for the purpose of sensing of a physical phenomenon. Sensor chips are incorporating semiconductor circuit elements, used to convert changes to some physical parameter to an electrical signal. There are hundreds of different kind of sensor chips, they all can be flexible manufactured as a signal conditioning chip, a stand- alone transducer, or a comibination.
Sensor chips are ready and can be used directly or they can be functionalized according to the customers need in a simple process using established conjugation techniques. Each sensor chip has 54 mologram structures and since every mologram has its own focal point, parallel label-free multiplexing can be achieved easily. In combination with a single or six-chanell fluidic chamber, different sensor chip formats can be implemented via simple combinatorics.
Our Sensor Chips are backfilled, meaning measurements in real complex biological media is possible. This enables a vast range of different assays in a flexible, fast and automated way. We offer different sensor chips for different applications, for example characterizing antibodies with molographic measurements in real complex biological samples with our Protein A Sensor chip is possible.
