Universal Chip Architecture

Sensor Chips

Our universal chip architecture can tackle various applications addressing major pain points in novel cell and gene therapy. Know-how of 10 years is embedded in chip coating & ability to structure active lines to serve as molecular lens on chip surface. 

lino Biotech sensor chip

One Chip Design.
Endless Opportunities

Our universal chip architecture can tackle various applications addressing major pain points in novel cell and gene therapy. Biological functionalization of a MoloChip can be easily achieved by DNA-directed immobilization with a set of well characterized DNA sequences.

Orthogonal nature of the DNA directed immobilization in combination with the provided single – or six channel flow chambers allows for various subset combinations of lino´s MoloChips. Our sensor chips are ready for you to be used or they can be functionalized according to our customers needs in a simple process using established conjugation techniques. Each sensor chip has 54 mologram structures which can be functionalized in various ways. Since every mologram has its own focal point, parallel label-free multiplexing can be achieved easily. In combination with a single or six-chanel fluidic chamber, different sensor chip formats can be implemented via simple combinatorics. Possible applications of molography are vast. They range from the investigation of a specific biomolecular interaction in basic biological research to the diagnosis of a critical health condition in an emergency. To sum it up, in molography, biomolecules on a chip become apparent through diffraction, their coherent signal standing out from the speckle background generated by randomly arranged scatterns. The signal is hardly affected by changes due to temperature or buffer changes, or nonspecific bindings.

The sensor chip production is our core know-how. We successfully built on the established lithography-based single sensor fabrication process, two further suitable industrially accepted fabrication methods are currently under development. We have established a partner network to develop the four major components (the Optomechanic, the sensor chip, the liquid handling, the data evaluation software), while the operating software is being programmed inhouse by lino Biotech´s employees.

lino Biotech´s Sensor Chips

Our sensor chips are ready for you to be used or they can be functionalized according to our customers needs in a simple process using established conjugation techniques. Each sensor chip has 54 mologram structures which can be functionalized in various ways. Since every mologram has its own focal point, parallel label-free multiplexing can be achieved easily. In combination with a single or six-chanell fluidic chamber, different sensor chip formats can be implemented via simple combinatorics.

1x Molochip

1 capture single stranded DNA (ssDNA) sequence* fabricated by dip-coating or flow chamber modification.

6x Molochip

6 orthogonal capture ssDNA sequences fabricated by flow chamber modification or micro spotting.

54x Molochip

54 orthogonal capture ssDNA sequences fabricated by micro spotting.

*colors represent different chemical functionalities

Sensor Chips
– An Overview

In general, incorporating semiconductor circuit elements, used to convert changes to some physical parameter to an electrical signal are defined as sensor chips. The size and the format usually differs between manufacturers. They can be a solid state potentiometric, ampermetric and/or conductometric microsensor device or also an integrated group of such devices. The optical configuration and the fluidics are important, and can be seen as the heart of an biosensor. In our case, lino Biotech´s universal sensor chip architecture can tackle various applications, used to address major pain points in novel cell and gene therapy. Biological functionalization of a MoloChip can be easily achieved by DNA-directed immobilization with a set of well characterized DNA sequences. Orthogonal nature of the DNA directed immobilization in combination with the provided single – or six channel flow chambers allows for various subset combinations of lino´s MoloChips.

We offer contract research. Interested for more?

Frequently asked questions

A sensor is a device that produces an output signal for the purpose of sensing of a physical phenomenon. Sensor chips are incorporating semiconductor circuit elements, used to convert changes to some physical parameter to an electrical signal. There are hundreds of different kind of sensor chips, they all can be flexible manufactured as a signal conditioning chip, a stand- alone transducer, or a comibination.

In general, incorporating semiconductor circuit elements, used to convert changes to some physical parameter to an electrical signal are defined as sensor chips. The size and the format usually differs between manufacturers. They can be a solid state potentiometric, ampermetric and/or conductometric microsensor device or also an integrated group of such devices. The optical configuration and the fluidics are important, and can be seen as the heart of an biosensor. In our case, lino Biotech´s universal sensor chip architecture can tackle various applications, used to address major pain points in novel cell and gene therapy. Biological functionalization of a MoloChip can be easily achieved by DNA-directed immobilization with a set of well characterized DNA sequences. Orthogonal nature of the DNA directed immobilization in combination with the provided single – or six channel flow chambers allows for various subset combinations of lino´s MoloChips.

Sensor chips are ready and can be used directly or they can be functionalized according to the customers need in a simple process using established conjugation techniques. Each sensor chip has 54 mologram structures and since every mologram has its own focal point, parallel label-free multiplexing can be achieved easily. In combination with a single or six-chanell fluidic chamber, different sensor chip formats can be implemented via simple combinatorics.

Our Sensor Chips are backfilled, meaning measurements in real complex biological media is possible. This enables a vast range of different assays in a flexible, fast and automated way. We offer different sensor chips for different applications, for example characterizing antibodies with molographic measurements in real complex biological samples with our Protein A Sensor chip is possible.

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