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Sensor chips for MACS Matchmaker

Find the right sensor chip for your scientific question!

At the heart of the MACS® Matchmaker platform are Lino Biotech’s proprietary sensor chips, engineered to deliver precise and reliable measurements of molecular interactions. Each chip is fabricated on an advanced optical waveguide, ensuring exceptional data quality.

The sensor surface is arranged as a highly versatile 8 × 8 array, resulting in 64 individual sensors. This architecture enables true parallelization, maximizing data throughput and allowing multiple conditions, replicates, or controls to be measured simultaneously.

Combined with integrated microfluidic flow channels, the consumable design incorporates the fluidics directly into the sensor. This approach not only simplifies handling but also significantly reduces the need for frequent instrument maintenance, even when working with crude or complex biological samples such as cell lysates, blood, or culture supernatants.

To further adapt to diverse research needs, lino Biotech offers two state-of-the-art immobilization strategies. These solutions provide flexibility in ligand coupling, supporting a broad spectrum of applications ranging from antibody characterization to small-molecule drug discovery.

 

Click_chemistry_chips

Click Chemistry Chips

provide robust and covalent immobilization of biomolecules onto the sensor surface. Using an optimized Click Chemistry strategy, these chips ensure long-term stability and compatibility with a wide range of biomolecular targets. The 2D PEG layer with the integrated molographic template guarantees low non-specific binding, making it ideal for applications that require durable and high-performance sensing surfaces. They are ideal if you only have limited amount of ligand, however as any covalent immobilization they require the development of a regeneration protocol for each immobilized target. 

DNA_immobilization

DNA sensors chips

are equipped with pre-defined DNA oligonucleotide patterns (20 mers) that enable specific and versatile target immobilization. Using palindromic DNA-sequence linkers, these chips simplify functionalization for a variety of biomolecules. They are particularly suited for multiplexed analysis, as they facilitate simultaneous evaluation of multiple interactions on the same chip. In addition, they are easily regeneratable and usually no custom regeneration protocols need to be developed. The DNA can simply be dehybridized and a new DNA conjugated molecule or adaptor can be applied.

    Sensor chips for MACS Matchmaker

    Find the right sensor chip for your scientific question!

    Lino Biotech offers two cutting-edge immobilization solutions tailored to fit diverse research needs:


    DNA_immobilization

    DNA sensors chips

    are equipped with pre-defined DNA oligonucleotide patterns (20 mers) that enable specific and versatile target immobilization. Using palindromic DNA-sequence linkers, these chips simplify functionalization for a variety of biomolecules. They are particularly suited for multiplexed analysis, as they facilitate simultaneous evaluation of multiple interactions on the same chip. In addition, they are easily regeneratable and usually no custom regeneration protocols need to be developed. The DNA can simply be dehybridized and a new DNA conjugated molecule or adaptor can be applied.

    Click_chemistry_chipsClick Chemistry Chips

    provide robust and covalent immobilization of biomolecules onto the sensor surface. Using an optimized Click Chemistry strategy, these chips ensure long-term stability and compatibility with a wide range of biomolecular targets. The 2D PEG layer with the integrated molographic template guarantees low non-specific binding, making it ideal for applications that require durable and high-performance sensing surfaces. They are ideal if you only have limited amount of ligand, however as any covalent immobilization they require the development of a regeneration protocol for each immobilized target. 

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While both solutions are designed to advance biomolecular interaction studies, each offers distinct features and advantages. In combination with our DNA adaptors, they provide a complete and flexible toolkit for immobilization strategies across diverse applications. Thanks to their robust design, high combinatorial capacity, and ease of use, Lino Biotech’s sensor chips form the technological backbone of focal molography – empowering researchers to gain deeper insights into complex biomolecular interactions with unmatched sensitivity and reliability.

In case you are looking for a customized solution, please contact us via sales@lino-biotech.com

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