Literature on Focal Molography
Explore peer-reviewed publications, scientific posters, application notes, brochures and webinars on focal molography and label-free biomolecular interaction analysis.
Jun, 2026
High-Throughput Binding Kinetic Measurements of DNA-Encoded Library-Derived Hits by Focal Molography
Favalli, N., Velti, C., Campari, L., Heuberger, L., Fabbri, M., Müller, M., Puglioli, S., Cazzamalli, S., Neri, D., Frutiger, A., & Oehler, S. (2026). ...
2026
Organization and Dynamics of Focal Adhesions: Light Diffraction Analysis of Cellular Adhesion on Nanopatterned Surfaces
Szekacs, I., Novák, S., Kovacs, B., Dicső, Z., Péter, B., Bonyár, A., Popov, R., Frutiger, A., & Horvath, R. (2026). ACS Applied Materials & ...
May 28, 2026
Focal Molography in Complex Media
In this live webinar, Prof. Dominik Meinel (FHNW) presents how focal Molography enables label-free biomolecular interaction analysis in complex media — ...
May, 2026
High-Throughput Pharmacologic Activity Profiling of Antibodies
Poster presented at PEGS Boston 2026 (Booth 615, Poster A073). Demonstrates an 8-plex Fc receptor profiling panel, anti-CD20 serum protein binding kinetics, ...
Jan 9, 2023
Screening 20 DNA-PROTAC Linkers in a Single Experiment
This scientific Poster presented at the "6th TPD & Induced Proximity Summit Europe" in London, UK (Mar 10-12, 2026) by Dr. Andeas Frutiger investigates ...
2026
Investigations into Linker Effects of DNA-VHL Ligand Conjugates by Multiplexed Affinity Measurements Using Focal Molography
Raschke, P., Notova, S., Gatterdam, V., Frutiger, A., & Brunschweiger, A. (2026). RSC Chemical Biology, Advance Article. https://doi.org/10.1039/D6CB00011H
Nov 11, 2025
MACS® Matchmaker - Biomolecular Interaction Analysis in Real Samples
This scientific poster, presented at the "PEGS Europe 2025" conference in Lisbon, PT (Nov 11-23, 2025), describes four different examples in which focal ...
Nov 10, 2025
Anti-His-tag capture system – fast, reversable and convenient protein immobilization
This application note describes a straightforward protocol for immobilizing His-tagged proteins to the surface of biosensor chips used on the MACS® Matchmaker ...
Oct 21, 2025
Accelerating Drug Discovery with focal molography
This scientific poster, presented at the "ELRIG Drug Discovery 2025" meeting in Liverpool, UK (Oct 21-22, 2025), describes an innovative solution for the ...
Sep 30, 2025
Exploring beta-catenin and TCF4 interaction in complex environments by means of novel biosensing platform focal molography
Philipp Cedro, Roman Popov, Maxime Karrer, Jean-Christophe Hau, Eric-André Kusznir, Ralf Thoma, Andreas Frutiger, Matthias Lauer, Sylwia Huber PLoS One ...
Aug 11, 2025
On-DNA Hit Validation from DNA-Encoded Library Screenings by Focal Molography
This scientific poster, presented at the "13th International Symposium on DNA-Encoded Chemical Libraries" in Boston, MA, USA (Aug 14-15, 2025), describes a ...
Apr, 2025
Anti-Fc capture system – convenient and fast immobilization of antibodies
The document introduces an anti-Fc capture system designed for rapid and convenient immobilization of antibodies on focal Molography sensor chips. Based on ...
Mar, 2025
MACS® Matchmaker Instrument Brochure
Comprehensive overview of the MACS® Matchmaker label-free biosensor platform, including kinetic characterization modes (SCK, MCK), concentration determination, ...
Jan, 2025
Anti-biotin capture system – fast and easy solution for the immobilization and characterization of your biotinylated ligands
The document presents the development of an anti-biotin capture system for focal Molography to enable straightforward immobilization and kinetic ...
Jan 22, 2025
Focal Molography Allows for Affinity and Concentration Measurements of Proteins in Complex Matrices with High Accuracy
Dirscherl, L.; Merz, L.S.; Kobras, R.; Spies, P.; Frutiger, A.; Gatterdam, V.; Meinel, D.M. Focal Molography Allows for Affinity and Concentration Measurements ...
Nov, 2024
Fast and convenient hit validaton for DNA-encoded libraries
The document describes the integration of focal Molography with DNA-encoded library (DEL) technology to streamline the screening and validation of small ...
May, 2024
Context Matters - Real Samples, Real Results with Label-free Technology
The experiments highlighted the method’s reliability in differentiating molecular interactions in both PBS-T buffer and human serum. Using anti-GFP VHH, the ...
March, 2024
Characterizing small molecule hits from DNA- encoded library screenings by focal Molography
Teh document shows the integration of focal molography with DNA-encoded library (DEL) technology, streamlining drug discovery by enabling efficient screening ...
Sep, 2021
Total internal reflection focal molography (TIR-M)
Blickenstorfer, Y., Borghi, L., Reichmuth, A. M., Fattinger, C., Vörös, J., & Frutiger, A. (2021). Sensors and Actuators B: Chemical, 349, 130746.
Mar, 2021
Quantitative Diffractometric Biosensing
Blickenstorfer, Y., Müller, M., Dreyfus, R., Reichmuth, A. M., Fattinger, C., & Frutiger, A. (2021). Physical Review Applied, 15(3), 034023.
Feb, 2021
Investigating complex samples with molograms of low-affinity binders
Reichmuth, A. M., Kübrich, K., Blickenstorfer, Y., Frutiger, A., Momotenko, D., Gatterdam, V., ... & Vörös, J. (2021). ACS sensors, 6(3), 1067-1076.
Jan, 2021
Ultra-Stable Molecular Sensors by Sub-Micron Referencing and Why They Should Be Interrogated by Optical Diffraction—Part I. The Concept of a Spatial Affinity Lock-in Amplifier
Frutiger, A., Fattinger, C., & Vörös, J. (2021). Sensors, 21(2), 469.
Dec, 2020
Ultra Stable Molecular Sensors by Submicron Referencing and Why They Should Be Interrogated by Optical Diffraction—Part II. Experimental Demonstration
Frutiger, A., Gatterdam, K., Blickenstorfer, Y., Reichmuth, A. M., Fattinger, C., & Vörös, J. (2020). Sensors, 21(1), 9.
May, 2020
Quantification of Molecular Interactions in Living Cells in Real Time using a Membrane Protein Nanopattern
Reichmuth, A. M., Zimmermann, M., Wilhelm, F., Frutiger, A., Blickenstorfer, Y., Fattinger, C., ... & Vörös, J. (2020). Analytical chemistry, 92(13), ...