Fast and convenient hit validation for DNA-encoded libraries
The document describes how focal molography works with DNA-encoded library (DEL) technology to simplify screening and validation of small molecule hits in drug discovery. The method characterizes the kinetics of up to 54 compounds in a single step. It saves time and shows binding behavior in physiologically relevant environments.
More videos and webinars
14:19
Sep 9, 2026
Development of an Fc-Capturing Protein for High-Throughput Screening at Miltenyi Biotec
Artem Siemens
Capture and immobilization · Antibodies and Fc biology
Recorded at the 3rd focal Molography User Meeting, Artem Siemens (Miltenyi Biotec) shows how a homodimeric capture nanobody, immobilized by DNA-directed immobilization (DDI), ...
Watch after a short form
3:34
Jul 2026
On-DNA Kinetics at Philochem: What SPR Cannot Deliver
Nicholas Favalli
DEL and hit validation
Kinetic profiles for DEL hits that Biacore SPR and fluorescence polarization could not resolve, obtained directly on-DNA with focal molography.
4:43
Jul 2026
DEL Hit Validation: The On-DNA Advantage
Joshua Alper, PhD
DEL and hit validation
Why on-DNA binding confirmation matters at the pharma-portfolio level, and how focal molography enables validation in biologically relevant matrices.