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Application note

Parallel kinetic validation of DNA-encoded library hits

lino Biotech AG ·Oct 2026

KineticsHit ValidationMultiplexing

Twenty-four on-DNA hits from a DEL selection, validated in parallel against CAIX and the antitarget CAII on one focal molography chip, without purification. Four sub-nanomolar binders with more than 10,000-fold selectivity, and the active stereoisomer of each hit, from the same runs.

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Recorded at the 3rd focal Molography User Meeting, Artem Siemens (Miltenyi Biotec) shows how a homodimeric capture nanobody, immobilized by DNA-directed immobilization (DDI), ...

KineticsMultiplexing

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A multiplex Fc receptor panel on focal molography maps where omalizumab, ligalizumab and their immune complexes with IgE and allergen bind, across all human Fc gamma and IgE ...

KineticsMultiplexing

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User Meeting talk

26:18 Sep 9, 2026

Focal Molography Enables Rapid Evaluation of Miniprotein Plasma Protein Binding

Alyssa Anderson

Head of Protein Characterization·AI Proteins

Complex media

Plasma protein binding of 15 designed miniproteins measured directly in plasma on one 64-plex chip, validated against ultracentrifugation and extended by kinetic information.

AffinityKineticsMultiplexing

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