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What can the MACS Matchmaker answer for you?

Label-free binding kinetics, measured directly in the sample your question lives in.

Every application below is the same measurement seen from a different angle: how fast a complex forms, how long it lasts, and the affinity that follows from the two. Because the sample needs no purification and up to 64 ligands sit on one chip, a question that usually takes a campaign becomes a single run. Pick the one closest to yours.

 

Antibodies and proteins

Characterization that decides whether a candidate goes forward, run on the intact molecule in a relevant matrix.

Fc Receptor PanelEffector functionFc Receptor PanelEffector function across all seven human Fc receptors, on one chip in about an hour.Read moreFcRn Species PanelPharmacokineticsFcRn Species PanelAntibody half-life predicted across six preclinical species in a single run.Read morePolyreactivity PanelDevelopabilityPolyreactivity PanelFast clearance, aggregation and immunogenicity risk, caught before they kill a candidate.Read morePlasma Protein BindingADMEPlasma Protein BindingThe free fraction of a compound in plasma, measured before PK fails.Read moreBiosimilar ComparabilityComparabilityBiosimilar ComparabilityOriginator and biosimilar on the same mologram, so a matched pair returns no signal.Read more

Small molecules and encoded libraries

The compound stays on its DNA tag, so a hit list becomes a ranked series without an off-DNA synthesis campaign in between.

DEL Hit ValidationEncoded librariesDEL Hit ValidationScreening hits confirmed on their own DNA tag, in 90 minutes, without off-DNA synthesis.Read morePROTAC and Molecular GluesTargeted degradationPROTAC and Molecular GluesA whole linker series ranked in one experiment instead of one compound per day.Read moreEncoded Library ScreeningHit expansionEncoded Library ScreeningExpand a hit into a library and measure every single member.Read more

Prefer to send samples?

The same measurements are available as a service, without an instrument in your lab.

Custom Measurement ServiceServiceCustom Measurement ServiceSend samples, receive kinetics. No instrument required.Read moreDevelopability Data ServiceServiceDevelopability Data ServiceA developability package on your candidates, run by our scientists.Read more

Not sure which one fits your question?

Describe the interaction you need to measure and we will tell you whether the MACS Matchmaker is the right instrument for it, and how the experiment would look.

Talk to a scientist