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Complex-Matrix Kinetics

Your binding data is right.

Your candidate may still be wrong.

Conventional kinetics live in PBS. Real biology lives in serum, lysate, cell supernatant, where late-stage failures are decided.

MACS® Matchmaker measures kinetics in the matrices that actually predict outcomes.

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Introducing the MACS® Matchmaker 

Experience a robust platform that delivers quantitative data on binder affinity, kinetics, and specificity in complex samples. Unlock new possibilities in your research today – because every target deserves its perfect match!

Our first commercial instrument using focal molography technology, revolutionizes biological interaction measurement. This innovative approach provides a direct, undisturbed view of molecular dynamics in their natural state, without the need for labels, overcoming traditional research limitations like signal disturbance and non-specific binding. It's not just an instrument; it's a gateway to a new era of life sciences research, enabling real-time observation and quantification of biological processes. It is transforming biological research, paving the way for more accurate, efficient, and straightforward studies, heralding a groundbreaking future in molecular interaction research.

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MACS Matchmaker

Crude Media

in vivo-like environment and eliminate the hassle of pre-purification saving time.

Simple Assay

Leverage our easy-to-use sensor functionalization protocol to set up your experiments faster than ever.

Automatization

Use the MACS® sampler for fully unattended runs in combination with up to 2 x 384 well plates.

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Crude samples

Pre-purification eats weeks. Your binder fails when the matrix changes from buffer to lysate or serum.

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Background masks signal

Labels and NSB hide the real binding event. Real hits slip through as false negatives.

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Multi-week panels

Sequential SPR sweeps stall every decision. Cross-species FcRn, biosimilar comparability, off-rate ranking all wait in line.

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Sub-twofold gaps

Critical 1.5× differences disappear. Below the NSB floor, the data you need to rank candidates is invisible.

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One pair at a time

Conventional kinetics runs sample-by-sample. 64 simultaneous interactions stay on the to-do list.

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Drift-limited weak binders

Slow off-rates wash away in baseline drift before a clean curve can be fit.

Applications across drug discovery & antibody engineering

FcRn Species Panel

Stop bridging via surrogate species

Cross-species antibody half-life prediction in one experiment, on one chip, in approximately one hour.

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DEL Hit Validation

Validate hits in their selection matrix

High-throughput on-DNA hit validation directly from screen output, in crude lysate or buffer, without resynthesis.

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Fc Receptor Panel

Comparability below the SPR noise floor

Profile every Fc receptor (FcγRI/IIa/IIb/IIIa/IIIb plus H131/R131 and V158/F158 allele variants) on one chip in about one hour.

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Targeted Protein Degradation

Ternary complex in lysate, not in PBS

Ternary complex characterization for PROTACs and molecular glues, with cooperativity readouts directly from binding data.

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How it works

Read the binding, not the background.

Focal molography reads coherent mass density directly. Only specifically bound analyte counts toward signal. Non-specific binding, drift, and matrix noise stay invisible — so kinetics measured in serum, lysate, or cell supernatant deliver the same precision as buffer.

What our customers say

Your next failed candidate doesn't have to be a surprise.

Bring your antibody, your PROTAC, your DEL hit. Run it on a real matrix. See whether the data your decision rests on actually predicts.

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