About this video
A short compilation of statements from researchers who use the MACS Matchmaker platform in their daily work.
Why they use focal molography
Interviewees explain how the technology delivers high sensitivity, robustness, and kinetic precision in real biological samples. They describe focal molography as a validation tool for DEL hits that has changed their early drug discovery workflows.
For detailed customer perspectives, see the individual interviews with Joshua Alper and Nicholas Favalli.
More resources
Oct 2026
High-throughput thermodynamic fingerprinting of protein–ligand interactions by DNA-directed focal molography
Oehninger, J., Notova, S., & Frutiger, A. (2026). PLOS One, 21(10), e0354008. https://doi.org/10.1371/journal.pone.0354008
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Oct 2026
Same target, different stickiness: polyreactivity of therapeutic antibodies
Six clinical antibodies, including two same-target pairs, ranked by polyreactivity against an eight-ligand panel on one focal molography chip. Briakinumab scored 69-fold above ...
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Oct 2026
One on-DNA ligand against many targets: selectivity profiling for DEL hit validation
On-DNA oncoFAP profiled against human, mouse and canine FAP and five unrelated proteins on one focal molography chip layout. Full kinetics on every species variant, flat responses ...
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