Documents on Focal Molography
Peer-reviewed publications, application notes, scientific posters and brochures on focal molography and label-free biomolecular interaction analysis.
Jun 2026
Organization and Dynamics of Focal Adhesions: Light Diffraction Analysis of Cellular Adhesion on Nanopatterned Surfaces
Cell-based assays
Szekacs, I., Novák, S., Kovacs, B., Dicső, Z., Péter, B., Bonyár, A., Popov, R., Frutiger, A., & Horvath, R. (2026). ACS Applied Materials & Interfaces. ...
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Jun 2026
High-Throughput Binding Kinetic Measurements of DNA-Encoded Library-Derived Hits by Focal Molography
DEL and hit validation
Favalli, N., Velti, C., Campari, L., Heuberger, L., Fabbri, M., Müller, M., Puglioli, S., Cazzamalli, S., Neri, D., Frutiger, A., & Oehler, S. (2026). Journal of Medicinal ...
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May 2026
High-Throughput Pharmacologic Activity Profiling of Antibodies
Antibodies and Fc biology
Poster presented at PEGS Boston 2026 (Booth 615, Poster A073). Demonstrates an 8-plex Fc receptor profiling panel, anti-CD20 serum protein binding kinetics, and on-DNA DEL hit ...
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Mar 2026
Investigations into Linker Effects of DNA-VHL Ligand Conjugates by Multiplexed Affinity Measurements Using Focal Molography
Targeted protein degradation
Raschke, P., Notova, S., Gatterdam, V., Frutiger, A., & Brunschweiger, A. (2026). RSC Chemical Biology, Advance Article. https://doi.org/10.1039/D6CB00011H
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Mar 2026
Screening 20 DNA-PROTAC Linkers in a Single Experiment
Targeted protein degradation
This scientific poster was presented at the "6th TPD & Induced Proximity Summit Europe" in London, UK (Mar 10-12, 2026) by Dr. Andreas Frutiger. It investigates linker effects ...
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Nov 11, 2025
MACS® Matchmaker - Biomolecular Interaction Analysis in Real Samples
Complex media
This scientific poster was presented at the "PEGS Europe 2025" conference in Lisbon, PT (Nov 11-13, 2025). It describes four examples in which focal molography technology advances ...
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Nov 10, 2025
Anti-His-tag capture system: fast, reversible and convenient protein immobilization
Capture and immobilization
This application note describes a straightforward protocol for immobilizing His-tagged proteins to the surface of biosensor chips used on the MACS® Matchmaker platform.
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Oct 21, 2025
Accelerating Drug Discovery with focal molography
Technology
This scientific poster was presented at the "ELRIG Drug Discovery 2025" meeting in Liverpool, UK (Oct 21-22, 2025). It describes label-free detection and analysis of biomolecular ...
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Sep 2025
Exploring beta-catenin and TCF4 interaction in complex environments by means of novel biosensing platform focal molography
Complex media
Philipp Cedro, Roman Popov, Maxime Karrer, Jean-Christophe Hau, Eric-André Kusznir, Ralf Thoma, Andreas Frutiger, Matthias Lauer, Sylwia Huber PLoS One 20(9):e0333554. ...
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Aug 11, 2025
On-DNA Hit Validation from DNA-Encoded Library Screenings by Focal Molography
DEL and hit validation
This scientific poster was presented at the "13th International Symposium on DNA-Encoded Chemical Libraries" in Boston, MA, USA (Aug 14-15, 2025). It describes an on-DNA method ...
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Jul 2026
FcRn Species Panel: cross-species binding kinetics on a single chip
Antibodies and Fc biology
This application note resolves cross-species FcRn binding kinetics for two IgG1 antibodies against six species (human, cynomolgus, marmoset, rat, minipig, mouse). All values come ...
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Apr 2025
Anti-Fc capture system: convenient and fast immobilization of antibodies
Capture and immobilization
The document introduces an anti-Fc capture system for fast and convenient immobilization of antibodies on focal molography sensor chips. It is based on oligonucleotide-conjugated ...
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Mar 2025
MACS® Matchmaker Instrument Brochure
Technology
Comprehensive overview of the MACS® Matchmaker label-free biosensor platform, including kinetic characterization modes (SCK, MCK), concentration determination, integrated ...
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Jan 2025
Focal Molography Allows for Affinity and Concentration Measurements of Proteins in Complex Matrices with High Accuracy
Complex media
Dirscherl, L.; Merz, L.S.; Kobras, R.; Spies, P.; Frutiger, A.; Gatterdam, V.; Meinel, D.M. Focal Molography Allows for Affinity and Concentration Measurements of Proteins in ...
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Jan 2025
Anti-biotin capture system: fast and easy solution for the immobilization and characterization of your biotinylated ligands
Capture and immobilization
The document presents the development of an anti-biotin capture system for focal Molography to enable straightforward immobilization and kinetic characterization of biotinylated ...
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Nov 2024
Fast and convenient hit validation for DNA-encoded libraries
DEL and hit validation
The document describes how focal molography works with DNA-encoded library (DEL) technology to simplify screening and validation of small molecule hits in drug discovery. The ...
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May 2024
Context Matters - Real Samples, Real Results with Label-free Technology
Complex media
The experiments highlighted the method’s reliability in differentiating molecular interactions in both PBS-T buffer and human serum. Using anti-GFP VHH, the technique demonstrated ...
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Mar 2024
Characterizing small molecule hits from DNA-encoded library screenings by focal Molography
DEL and hit validation
The document shows how focal molography works with DNA-encoded library (DEL) technology for efficient screening and kinetic characterization of small molecules. This approach ...
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Sep 2021
Total internal reflection focal molography (TIR-M)
Technology
Blickenstorfer, Y., Borghi, L., Reichmuth, A. M., Fattinger, C., Vörös, J., & Frutiger, A. (2021). Sensors and Actuators B: Chemical, 349, 130746.
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Mar 2021
Quantitative Diffractometric Biosensing
Technology
Blickenstorfer, Y., Müller, M., Dreyfus, R., Reichmuth, A. M., Fattinger, C., & Frutiger, A. (2021). Physical Review Applied, 15(3), 034023.
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Feb 2021
Investigating complex samples with molograms of low-affinity binders
Complex media
Reichmuth, A. M., Kübrich, K., Blickenstorfer, Y., Frutiger, A., Momotenko, D., Gatterdam, V., ... & Vörös, J. (2021). ACS sensors, 6(3), 1067-1076.
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Jan 2021
Ultra-Stable Molecular Sensors by Sub-Micron Referencing and Why They Should Be Interrogated by Optical Diffraction—Part I. The Concept of a Spatial Affinity Lock-in Amplifier
Technology
Frutiger, A., Fattinger, C., & Vörös, J. (2021). Sensors, 21(2), 469.
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Dec 2020
Ultra Stable Molecular Sensors by Submicron Referencing and Why They Should Be Interrogated by Optical Diffraction—Part II. Experimental Demonstration
Technology
Frutiger, A., Gatterdam, K., Blickenstorfer, Y., Reichmuth, A. M., Fattinger, C., & Vörös, J. (2020). Sensors, 21(1), 9.
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May 2020
Quantification of Molecular Interactions in Living Cells in Real Time using a Membrane Protein Nanopattern
Cell-based assays
Reichmuth, A. M., Zimmermann, M., Wilhelm, F., Frutiger, A., Blickenstorfer, Y., Fattinger, C., ... & Vörös, J. (2020). Analytical chemistry, 92(13), 8983-8991.
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