Focal molography was introduced in our last article as a technology that detects molecular interactions without picking up environmental noise. This article walks through its other advantages: stability, speed, complex media, real time, label-free, multiplexing and miniaturization.
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Oct 2026
High-throughput thermodynamic fingerprinting of protein–ligand interactions by DNA-directed focal molography
Oehninger, J., Notova, S., & Frutiger, A. (2026). PLOS One, 21(10), e0354008. https://doi.org/10.1371/journal.pone.0354008
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Oct 2026
Same target, different stickiness: polyreactivity of therapeutic antibodies
Six clinical antibodies, including two same-target pairs, ranked by polyreactivity against an eight-ligand panel on one focal molography chip. Briakinumab scored 69-fold above ...
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Oct 2026
One on-DNA ligand against many targets: selectivity profiling for DEL hit validation
On-DNA oncoFAP profiled against human, mouse and canine FAP and five unrelated proteins on one focal molography chip layout. Full kinetics on every species variant, flat responses ...
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