Although SPR offers many advantages in biosensing, its potential is hampered by one key factor: environmental noise. Has any biosensor ever overcome this challenge? A novel technology, known as focal molography, is emerging as a contender in noise-free biosensing.
Understanding the environmental noise problem encountered and the high measurement precision needed in with surface plasmon resonance (and all refractometric biosensors) requires fundamental knowledge not only of how the desired binding signal is acquired in this technique, but also why we detect changes (noise) we are not interested in measuring.
