Fc Receptor Panel: real-time binding kinetics across seven human Fc receptors on a single chip

Seven human Fc receptors read in parallel on one focal molography chip in about one hour. Free omalizumab, free IgE and two immune complexes show how antigen loading switches the FcεRI signal off and rescales the whole FcγR fingerprint.
More videos and webinars
Development of an Fc-Capturing Protein for High-Throughput Screening at Miltenyi Biotec
Artem Siemens
Team Coordinator, Binder Discovery Group·Miltenyi Biotec
Recorded at the 3rd focal Molography User Meeting, Artem Siemens (Miltenyi Biotec) shows how a homodimeric capture nanobody, immobilized by DNA-directed immobilization (DDI), ...
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Focal molography for the Fc receptor profiling of therapeutic anti-IgE antibodies
Dr. Paul Engeroff
University of Bern
A multiplex Fc receptor panel on focal molography maps where omalizumab, ligalizumab and their immune complexes with IgE and allergen bind, across all human Fc gamma and IgE ...
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Focal Molography Enables Rapid Evaluation of Miniprotein Plasma Protein Binding
Alyssa Anderson
Head of Protein Characterization·AI Proteins
Plasma protein binding of 15 designed miniproteins measured directly in plasma on one 64-plex chip, validated against ultracentrifugation and extended by kinetic information.
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